The 38th Annual ChEGSA Symposium will be held on October 20th and 21st, 2016.
The annual ChEGSA research symposium started in 1979 with the hopes of showcasing the work of our graduate researchers, promoting intra-departmental research collaborations and connecting our students to industry. Today we continue these traditions, with the hopes of improving every year. This two-day event features graduate research presentations, a poster session, and a corporate-sponsored keynote address given by a distinguished professor from the field of chemical engineering. For a complete overview of the event, please see this year’s proceedings.
The Dow Chemical Company Keynote Address
Digital Drug Product Design: From Crystal Structure to Process Structure
Dr. Michael F. Doherty
Department of Chemical Engineering
University of California, Santa Barbara
Virtually all small molecular weight drugs are isolated as crystalline particles, and over 90% of all pharmaceutical products are formulated in particulate, generally crystalline form. Normally, the properties of the crystalline solid (especially polymorph and crystal shape) have a major impact on the functionality of the product as well as the design and operation of the manufacturing process, and in most cases the two cannot be considered separately.
Batch processing is the traditional method for producing drug products, which suffers from several drawbacks, including batch-to-batch variability and high manufacturing costs. The major name-brand drug companies are becoming more interested in developing continuous manufacturing processes, but these too have their own challenges, particularly speed & cost of process development, and forbidden recycles. I will report on recent innovations for (1) polymorph selection by continuous processing, (2) predicting crystal morphology for each polymorph, (3) bounding the maximum and minimum achievable particle sizes as a function of the key process design variables using attainable region concepts. Some remaining challenges will be discussed.
About the Speaker
Professor Michael F. Doherty earned his Bachelor of Science degree in Chemical Engineering from Imperial College, University of London in 1973 and his PhD from Trinity College, University of Cambridge in 1977. He was named one of the ‘One Hundred Chemical Engineers of the Modern Era (post 1945)’ by the American Institute of Chemical Engineers (AIChE) in 2008. In 2012, Professor Doherty received the E. V. Murphree Award in Industrial and Engineering Chemistry from the American Chemical Society (ACS) while he served as the Chair of the Department of Chemical Engineering at the University of California, Santa Barbara.
Professor Doherty’s research interests include process and systems engineering, with a focus on combining reactions and separations, crystallization of organic materials, and systems with complex chemistries. Currently he holds four U.S. and international patents. He has received numerous honors and awards for his teaching and research, including the Alpha Chi Sigma Award for Chemical Engineering Research (2004) and three divisional research awards from AIChE. We are excited to have him join us at Carnegie Mellon for the 2016 ChEGSA Symposium!